The methodological quality was low: only 23% of the trials reported adequate allocation concealment and only 46% were considered adequately double-blinded. Milk thistle is considered safe in dosages of 420 mg/day orally in divided doses for up to 41 months. Milk Thistle and Alcohol: Finding the Guardian Angel of the Liver. The liver is actually a large gland. It is not uncommon for alcoholics to take milk thistle as a preventive for liver damage or taking it with the hopes of stopping the progression of current damage. A meta-analysis of six studies of milk thistle and chronic alcoholic liver disease, found that four reported significant improvement in at least one measurement of liver function with milk thistle compared with a placebo. Milk Thistle is a popular remedy which is said to be beneficial for people who overindulge in alcohol. In the middle ages it was used to treat liver problems and in the 1500s it was used for emotional distress. The seeds contain about 3-6% silymarin so you need to take about 1/2 ounce of seeds ... Read More. Dosing. Thirteen randomised clinical trials assessed milk thistle in 915 patients with alcoholic and/or hepatitis B or C virus liver diseases. You can but... : Apparently you need to take quite a bit to have much of a benefit. TUDCA is after drinking where before causes more damage than alcohol alone. i heard that milk thistle need alcohol to extract sylamarin so it's hard to take it as tea.can't i eat the seeds directly from the plant fresh? Milk thistle has been used for over 2,000 years originating in ancient Greece where it initially was used for snakebites. 39 years experience Holistic Medicine. We know that one of the most serious complications alcoholism results in is liver damage. NAC is 30 mins or more before drinking after causes more damage than alcohol alone. We know that one of the most serious complications alcoholism results in is liver damage. And it needs to be large for it plays a major role in numerous functions in the human body, including: metabolism, regulation of glycogen storage (cell energy), decomposition of red blood cells (oxygen transport), plasma protein synthesis, hormone production, and detoxification. Dr. Randy Baker answered. One study specifically looking at acute viral hepatitis showed significant improvement in liver enzyme levels after 28 days of milk thistle supplementation. Milk Thistle is to be taken after drinking not before. Milk Thistle can also be used by individuals who are undergoing alcoholism detox to help rid the liver of alcohol and promote a healthy liver. Milk thistle is most commonly evaluated for use in the management of liver diseases (alcohol-induced and viral hepatitis) but the majority of clinical trials show equivocal results. We’ll also explore milk thistle dosages for specific health conditions, including non-alcoholic fatty liver disease. 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